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[118] confirmed that dapagliflozin decreases activation of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasomes and reduces the levels of IL-1, IL-6, TNF-, and caspase-1 in an adenosine monophosphate (AMP)-activated protein kinase (AMPK)-dependent manner, thereby ameliorating myocardial fibrosis and reshaping left ventricular function

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The strongest real-world evidence comes from a retrospective cohort analysis published in the Journal of the Endocrine Society