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The exact mechanism of GLP-1 receptor agonists for weight reduction is unclear, but they are thought to slow gastric emptying and possibly reduce appetite via central nervous system effects

The expansion of the United States semaglutide market is propelled by the rising incidence of obesity and type 2 diabetes, the growing need for GLP-1 receptor agonists, and the expanding use of weight-loss therapies
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Diabetologia (2018) 61(Suppl 1):S1620 (abstract 714)

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