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Endocrinology 146: 45144523, 2005

1) Garvey WT

The total impact score for each combination therapy was obtained by summing the individual pathway impact scores, calculated by the Disease Node Impact Score (as described in Section Estimating DM2 DMTs Drug Impact Effect Scores in the DM2-AD comorbidity network) for the pathways modulated by the respective drugs

Essentially, they slow down the gastric emptying, increasing the feeling of fullness

Plot twists are coming!

There are some groups of people in which metformin shows clear weight benefitsbut it isnt a magic pill. Metformin does not replace the need for a balanced diet and adequate physical activity