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4e) whereas Ex4 treatment had no effect on glycaemia (Fig

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Wadden, Ph.D., Sean Wharton, M.D., Pharm.D., Koutaro Yokote, M.D., Ph.D., et al., for the STEP 1 Study Group* 2


GLP-1 agonists like semaglutide (brand names Wegovy and Ozempic) and tirzepatide (brand names Mounjaro and Zepbound) have revolutionized obesity treatment

Success will depend on aligning biological insight with modern pharmacologic design, realistic regulatory strategies, and clinically meaningful endpoints
