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Addressing these challenges in pediatric populations requires developing and evaluating cost-effective pathways and strategies to mitigate the economic impact and improve patient outcomes

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This could relate to different pharmacokinetic profiles, lower peak drug levels, or differences in how the oral versus injectable forms interact with the nervous system

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For patients with well-controlled Graves disease who are euthyroid on antithyroid medications or following definitive treatment (radioactive iodine or thyroidectomy), tirzepatide may be considered if there are appropriate indications such as type 2 diabetes or obesity (BMI 30 kg/m or 27 kg/m with weight-related comorbidities)

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Due to utilizing objective criteria for study selection, no disagreements between reviewers occurred

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Its mechanism isnt fully understood

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