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In this study, 422 participants who lost over 5% of initial body weight on a low-calorie diet were randomized to liraglutide 3.0 mg or placebo for 56 weeks

L., Corsi Romanelli, M

Furthermore, semaglutide is stabilized against degradation by the DPP-4 enzyme Semaglutide reduces blood glucose through a mechanism where it stimulates insulin secretion and lowers glucagon secretion, both in a glucose-dependent manner

doi: 10.2337/dc18-2156

5 A number of reasons have been suggested for this lack of efficacy in certain individuals, ranging from genetic mutations causing poor responses to pharmacokinetic differences and concomitant medical conditions

Langenbecks Arch Surg 408(1):115 Elhag W, El Ansari W (2022) Effectiveness and safety of liraglutide in managing inadequate weight loss and weight regain after primary and revisional bariatric surgery: anthropometric and cardiometabolic outcomes