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PU and BP obtained funding and supervised the study

GLP-1RA intervention was associated with a reduction in fasting insulin levels when compared to those given metformin or placebo (MD = 1.40

In particular, in murin models, GLP-1 RAs have demonstrated to prevent meal-initiation-inhibiting activity on arcuate nucleus and inducing meal-ending actions on lateral parabrachial nucleus [24]

So, the researchers set out on a molecular fishing expedition in a pancreatic beta cell line

Furthermore, in periodontal disease, liraglutide was also found to downregulate M1-associated surface markers and cytokines, such as CD11c (Itgax), thereby reducing the proportion of M1 macrophages in gingival tissues and alleviating alveolar bone loss