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Description
preparation of compound 4: after being activated, the compound 3 and the amino at the end position of Arg34GLP-1 (9-37) in the compound 2 are subjected to acylation coupling reaction under the action of a condensation reagent and alkali to obtain a compound 4

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No large randomized controlled trials have directly compared combined therapy against semaglutide monotherapy, leaving prescribers to rely on case reports and clinical judgment

Front Physiol 2020;11:963.ArticlePubMedPMC 29

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Answering that question properly requires integrating clinical trial data, receptor pharmacology, post-marketing safety surveillance, genetic evidence, and patent analysis into a single coherent picture
