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Compounded drugs are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review

Although they provide benefits in symptom management and functional capacity in HFpEF, clinicians should watch out for the impact of GI adverse events to ensure safe and balanced treatment decisions
PMID: 39266553 Arch Pharm Res Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration

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However, the anatomic distribution of the L-cells (highest number in distal gut) and the rapid increase in postprandial circulating GLP-1 (35) that occurs before nutrients reach the distal gut (8, 63) is evidence supportive of neural, endocrine and/or paracrine mechanisms being more critical to nutrient-induced increases in circulating GLP-1 (164)
