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Compounded drugs are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review

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Although they provide benefits in symptom management and functional capacity in HFpEF, clinicians should watch out for the impact of GI adverse events to ensure safe and balanced treatment decisions

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PMID: 39266553 Arch Pharm Res Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration

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However, the anatomic distribution of the L-cells (highest number in distal gut) and the rapid increase in postprandial circulating GLP-1 (35) that occurs before nutrients reach the distal gut (8, 63) is evidence supportive of neural, endocrine and/or paracrine mechanisms being more critical to nutrient-induced increases in circulating GLP-1 (164)

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