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In some circumstances, it may also be prescribed off-label to treat overweight and obesity

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Chronic colonic delivery of propionate, for example, has been associated with reduced body weight and liver fat accumulation in experimental and early human studies

Among participants who met criteria for metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) at baseline, more than 80% in the 8mg and 12mg cohorts no longer met those criteria after treatment effectively resolving their fatty liver disease