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GLP-1s may help with OA by: Reducing overall inflammation Protecting cartilage in your joints Helping people lose weight takes pressure off the knees and hips Making walking and movement easier over time Studies found that GLP-1 and SGLT2 medicines may lower the risk of needing a knee replacement (for OA), though results varied

Analysis of 11 studies of older and newer GLP-1 weight loss drugs by the University of Oxford found that patients typically lost 8kg on weight loss jabs but returned to their original weight within 10 months of stopping them

Like treatments for high blood pressure or diabetes, they work best when patients receive ongoing care and support

PMID: 18046029

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You may increase three months later