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Weeks 912 7.5 mg once weekly Escalation dose An intermediate increase that may be prescribed after at least four weeks at 5 mg

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Cold chain shipping Some medicinal ingredients are susceptible to damage from heat, light and handling

Severe side effects are rare, although kidney failure, pancreatitis and a few other conditions have been reported

P = 0.009), but there was no correlation with changes in eGFR (Extended Data Table 2)

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