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A demonstrated medical need for treatment

GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine

doi: 10.1016/j.peptides.2009.06.019

That means compounded versions of these drugs made by smaller pharmacies and sold without FDA approval can no longer be legally produced or sold

Increased urination accompanied by the following symptoms may indicate inadequate diabetes control: Excessive thirst (polydipsia) : The combination of increased urination and persistent thirst suggests hyperglycaemia Unexplained weight loss : Despite Ozempic's weight-reducing effects, rapid or excessive weight loss with increased urination may indicate poor glycaemic control Fatigue and blurred vision : These symptoms alongside polyuria suggest elevated blood glucose levels Fruity-smelling breath : This may indicate diabetic ketoacidosis, a medical emergency requiring immediate attention - call 999 or go to A&E Other concerning presentations include: Urinary tract infection (UTI) : Increased frequency accompanied by burning sensation, cloudy or strong-smelling urine, lower abdominal pain, or fever requires prompt medical assessment