glp 1 osteoarthritis The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee | Journal of Inflammation Retrospective study examined 48 patients

Trelagliptin (syr-472, zafatek), novel once-weekly treatment for type 2 diabetes, inhibits dipeptidyl peptidase-4 (dpp-4) via a non-covalent mechanism

Ive lived with binge-eating disorder for like 25 yearsLiterally overnight, when I started taking it, it was like a switch had been turned off in my brain and all my thoughts about food vanishedSo the binge-eating has gone completely

Key Difference from GLP-1 While GLP-1 is all about metabolism and appetite, GLP-2 is the intestinal health specialist

Muscle Loss If appetite suppression is too high, protein and nutrient intake decreases, leading to: Muscle loss Increased fatigue Reduced metabolic rate Slower recovery after surgery Strength training and sufficient protein (1.2g per kg of body weight) are essential

Slow digestion, increasing fullness by delaying gastric emptying and prolonging nutrient absorption kinetics (NIH)

Abbreviations GLP-1RA: Glucagon-like peptide-1 receptor agonist(s) IPTW: Inverse probability of treatment weighting SGLT-2i: Sodium-glucose cotransporter 2 inhibitor(s) SIS: Suicidal ideation and self-injury VHS: Valencia Health System VID: Valencia Health System Integrated Database References Davies MJ, Aroda VR, Collins BS et al (2022) Management of hyperglycemia in type 2 diabetes, a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)