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Stout K, Daniels C, Aboulhosn J, et al

furthermore, the risk increases with longer treatment durations, higher doses, and when these agents are used for weight loss

While the half-life of endogenous GLP1 is short (~2 minutes) due to its rapid degradation by dipeptidyl peptidase-4 (DPP-IV), semaglutide has been engineered to resist DPP-IV-mediated degradation, prolonging its half-life to ~1 week (11-13)

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Conclusions: Tirzepatide use was associated with a lower observed risk of suicidal ideation or suicide attempts compared with other anti-obesity medications

Obesity-prone rats have normal bloodbrain barrier transport but defective central leptin signaling before obesity onset