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A central role of bile acid signaling as a novel pharmacological target in the metabolic syndrome and related diseases, such as obesity, T2D, atherosclerosis, liver disease, and cancer, is underscored by the presence of TGR5 in various tissues and cell types

The recently approved oral semaglutide should be taken with the recommended amount of water in the fasting state

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Hypoglycemia rates were similar across GLP-1 RA treatment groups, as shown in Table 4, and were primarily seen in patients treated with concomitant sulfonylurea (SU) therapy