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If symptoms persist despite these measures, patients should discuss with their provider whether maintaining the current tirzepatide dose longer before escalating might be appropriate

Summary: This highly anticipated Phase 3, event-driven, randomized, double-blind, active-controlled trial (SURPASS-CVOT) compared once-weekly tirzepatide (at maximum tolerated doses up to 15 mg) with once-weekly dulaglutide (1.5 mg) in over 13,000 adults with type 2 diabetes and established atherosclerotic cardiovascular disease

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