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To explain, lets learn some physiology first

Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions

Yan S, Marguet D, Dobers J, Reutter W, Fan H
Dehydration worsens nausea and is easy to overlook when your appetite is suppressed
PMID 21329779

The complaint lays out the science behind the allegation: tirzepatide is a large peptide molecule that digestive enzymes destroy before it can reach the bloodstream