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The dual-receptor action of tirzepatide may produce more pronounced gastric effects in some individuals, which could translate to higher heartburn rates

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It is not known if Wegovy will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people Do not use Wegovy if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Do not use Wegovy if: you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) you have had a serious allergic reaction to semaglutide or any of the ingredients in Wegovy injection or Wegovy tablets

Personal or family history of medullary thyroid carcinoma represents an absolute contraindication

Strong shelf differentiation

Infection points of the obesity indication were the FDA approval of high-dose semaglutide (Wegovy) in June 2021 and tirzepatide (Zepbound) in November 2023 specifically as chronic weight management drugs, where both drugs showed unprecedented efficacy in weight reduction, averaging 15-22% of baseline body weight in clinical trials