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Among the observational studies 39,45,46,49,50,51 comprised by the meta-analyses, two are worth a separate mention

CLINICAL APPLICATION OF GLP-1 IN LIPID METABOLISM AND ADIPOSE-RELATED DISORDERS Effects of glp-/glucose-dependent insulinotropic peptide dual agonists on lipid metabolism GLP-/glucose-dependent insulinotropic peptide (GIP) dual agonists are a new type of oral hypoglycemic drug, which can activate both GLP-1 and GIP incretin at the same time, thereby exerting a more comprehensive blood glucose control effect [125]

Finally, we screened reference lists from relevant published studies

acts centrally to reduce appetite Setmelanotide : Reserved for specific genetic obesity syndromes (e.g., POMC/PCSK1/LEPR deficiency, Bardet-Biedl syndrome) under specialist supervision Non-pharmacological interventions form the cornerstone of weight management and may be particularly appropriate: Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, increased physical activity, and behavioural strategies

Several questions remain to be answered

Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension