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The loss of muscle mass can contribute to a higher risk of falls and fractures, which can further exacerbate the decline in physical function

In summary, these data indicate that GLP-1 may inhibit -cell glucagon secretion via PKA-dependent modulation of N-type Ca 2+ channel activity in addition to its paracrine action via somatostatin [583]

(2019, August 27)

Rapid or extreme weight loss can accelerate lean mass and bone density decline , potentially increasing frailty and fracture risk

This is why low-carb diets are known as diuretics

Alli can still be a useful aid for eligible adults, but those with significant obesity or complex health needs may benefit more from discussing prescription-strength orlistat or other options with their GP