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In clinical studies of the FDA-approved tirzepatide products (Mounjaro and Zepbound), patients experienced significant reductions in body weight and improvements in metabolic markers when the medication was combined with diet and physical activity

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PMID: 40979545 Commun Biol 2026 Mar 31;9(1):705

A dysesthesia signal abnormal sensory perception was observed in approximately 21% of patients at the 12mg dose (compared to 0.7% with placebo), which is being monitored carefully in ongoing trials and warrants clinical attention

For many clients, this is the point in the year when it becomes easier to make a confident, informed decision about what their body needs heading into winter