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Combination therapies were shown to have stronger benefits regarding most of the measured parameters [including abnormalities in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, markers of systemic inflammation (clear reductions of IL-1 levels), liver inflammation, hepatocellular oxidative stress, hepatic fibrosis and hepatocyte apoptosis] vs

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CagriSema (cagrilintide + semaglutide) CagriSema is a fixed-dose combination of cagrilintide (a long-acting amylin analog) and semaglutide (the GLP-1 agonist behind Ozempic and Wegovy)

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Orlistat (brand names Xenical and Alli) is a lipase inhibitor that has been available in the UK since 1998