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As for the effects of chronic fat intake on GIP secretion, the expression of regulatory factor X 6 (Rfx6) and pancreatic and duodenal homeobox 1 (Pdx1), important transcription factors involved in GIP expression [67-69], was found to be increased in GIP-producing cells in high-fat diet (HFD)-induced obese mice, suggesting a possible mechanism for GIP hypersecretion in obesity [68, 70]
For weight management (semaglutide 2.4 mg/Wegovy), NICE recommends stopping treatment if less than 5% of initial body weight is lost at 6 months
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