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Four reasons GLP-1s affect sleep Circadian rhythm disruption GLP-1 receptors in the hypothalamus modulate GABA, orexin, and melatonin, shifting sleep-wake cycles Blood sugar fluctuations Your body adjusts to new overnight glucose patterns, disrupting sleep cycles during adaptation Physical side effects Night sweats, digestive discomfort, and nausea peak during the first 46 weeks and dose escalation periods Psychological factors Adjusting to a new relationship with food and body image can trigger anxiety or racing thoughts at night Free Resource Get Dr

As estrogen levels embark on their downward rollercoaster throughout perimenopause, muscle mass maintenance becomes more and more challenging

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62,63 Intestinal FXR mediates suppression of lipid absorption, while hepatic FXR inhibits lipid synthesis

However, three subsequent randomized control trials reported a neutral effect in airway inflammation with both available TZDs, pioglitazone and rosiglitazone