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In this trial, mean weight loss was comparable to that of individuals with obesity treated with semaglutide

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However, definitive cellular localization of GLP-1R mRNA transcripts or immunoreactive GLP-1R protein within human cardiomyocytes remains elusive, as validated GLP-1R antisera lack sufficient sensitivity to detect the expression of endogenous cardiac GLP-1R by Western blotting

While these medications commonly cause gastrointestinal side effects such as nausea and constipation, back pain is not listed as a characteristic adverse effect in FDA prescribing information

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Additionally, as part of the EVOKE trials, there are currently phase III trials conducted by Nordisk [62] investigating the use of semaglutide in the treatment of patients with early-stage AD [63]