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The phase II obesity study of retatrutide also included a MASH substudy to assess its effects on the amount of liver fat

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A series of clinical trials called SUSTAIN, which evaluated the drug in about 8,000 patients with type 2 diabetes, showed that semaglutide is more effective than other available drugs (sitagliptin, marketed as Januvia

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After certain GLP-1 receptor agonist drugs such as Ozempic and Wegovy were placed on the FDA drug shortage list, specialized pharmacies began compounding semaglutide and other similar peptide-based drugs for patients seeking to use them for weight loss purposes