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Chronic sleep disruption is associated with lower Akkermansia muciniphila populations in the gut microbiome, which creates a double hit, reduced GLP-1 sensitivity plus reduced microbial GLP-1 stimulation

CVS Caremark has an ongoing deal with Novo Nordisk

GLP-1 analogues delay gastric emptying ( When initiating GLP-1based therapy, clinicians should adhere to the principle of do no harm , particularly during the early phases of treatment when gastrointestinal adverse effects are most likely to emerge ( Potentially the easiest way to prevent nausea and vomiting is by starting at a low dose ( In most cases of Grade 1 or 2 nausea, maintaining the current dose for one to two additional dosing intervals is sufficient to allow symptom resolution

Cardiovascular strain: Your heart has to work harder to pump blood through additional tissue

Semaglutide (Ozempic/Wegovy) is more effective at reducing blood sugar levels than liraglutide (Saxenda)