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As of 2021, an estimated 537 million people globally have diabetes

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Resistance when drawing or injecting If the solution seems thicker than usual, requires more pressure to draw into the syringe, or feels different during injection, aggregation may have increased the viscosity

The mean duration of follow-up varied among the studies, ranging from 6 to 48 months, with an average follow-up period of 39 months

Topical interventions provide additional relief for select patients

Wilding JP, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF