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Mitochondrial dysfunction is a key contributor to the pathophysiology of neuropathic pain

body weight decreased in a dose-dependent manner and there was a dose-dependent reduction in appetite [62]

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GLP-1 agonists, Cleveland Clinic (2023) Nutritional modulation of endogenous glucagon-like peptide-1 secretion: A review , Nutrition & Metabolism (2016) Closing Americas fiber intake gap, American Journal of Lifestyle Medicine (2016) Easy ways to boost fiber in your daily diet, Academy of Nutrition and Dietetics (2021) The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon, The American Journal of Physiology-Gastrointestinal and Liver Physiology (2018) Mediterranean diet effects on Type 2 diabetes prevention, disease progression, and related mechanisms

It's a region involved in emotion and the reward system

Interestingly, research on vildagliptin indicates that DPP4 inhibition may also improve insulin sensitivity in type 2 diabetes, as shown through indirect assessments of insulin sensitivity [52] and the hyperinsulinemic euglycemic clamp test [60]