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The OR calculated using MantelHaenszel and Peto's method showed a similar lack of difference between the two groups (Figures S14 and S15, respectively)

Accordingly, preclinical AD and PD models suggest that dual and triple agonists may enhance neurotrophic and neuroprotective actions, while reducing A and -synuclein pathology, oxidative stress, and inflammation (49, 208, 209)

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"These drugs are inherently complex to compound safely, and the risks they pose to patient safety far outweigh any benefits," Novo Nordisk said in a statement