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Lipohypertrophy is thickening or lumping of fatty tissue that can occur with repeated injections in the same spot

Allowing the medication to reach room temperature before injection (if refrigerated) makes the solution less shocking to tissue and minimizes the stinging sensation many patients report

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This introduces a risk of selection bias and incomplete retrieval of evidence

One to two months of baseline migraine data, recording frequency, severity, duration, and triggers, provides the comparison point you need to evaluate any change after starting the medication

Injecting into wet skin can cause stinging