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Most notably, none of the included trials was able to formally assess the impact of semaglutide treatment on the development of comorbidities or the prevention of cardiovascular events

Somatostatin-14 has been the primary focus for optimization and anticancer drug development

7 Clinical Trials Testing GLP-1 Receptor Agonists in Patients with AD or PD (Table 1) 7.1 A Pilot Study Testing Exendin-4 (Byetta , Bydureon , Exenatide) in PD A pilot study of the potential neuroprotective effects of GLP-1 receptor agonist exendin-4 was conducted as an open-label trial in participants with PD (NCT01174810)

However, the FDA has expressed concern about some compounded versions of semaglutide using ingredients like semaglutide sodium or acetate, which are not listed on the FDAs approved drug shortage list and haven't been evaluated for safety or efficacy in compounded use