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Sam Fazeli, director of research at Bloomberg Intelligence, said in a best-case scenario that the drug could only be launched in 2028, at which stage multiple competitors might be available. Outpaced by rivals Danuglipron was designed as a needle-free alternative to popular weight-loss shots from Novo Nordisk A/S and Eli Lilly & Co

Receptor density in cardiovascular and immune tissues is, however, markedly lower than in the pancreas, and the modest physiological increment in GLP-1 produced by DPP-4 inhibition does not appear sufficient to drive the downstream signaling needed for anti-inflammatory, endothelial, or plaque-modifying effects [13], [14], [28]

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DISCUSSION Although the prevalence and clinical impact of AF in people with HFpEF are well recognized, 1,2,9 there are few data exploring this relationship in the context of obesity-related HFpEF