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Confidence gains were highest among millennials (77%), followed by Gen X (72%) and Gen Z (71%)

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Long-term opioid therapy often leads to reduced analgesic efficacy, requiring higher doses that increase the risk of dependency and adverse effects [79]

Adipose tissue aromatizes testosterone to estrogen and contributes to systemic inflammation and insulin resistance, all of which can disrupt the hypothalamicpituitarygonadal (HPG) axis and spermatogenesis