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These data demonstrate that the effects of semaglutide-induced weight loss are not restricted to individuals with very high BMI but apply across the entire spectrum of obesity

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By focusing on these high-risk but undertreated groups, our work aims to extend trial findings to routine practice and to inform strategies for improving secondary prevention and ensuring equitable access to cardioprotective therapies. GLP-1 use after MI or stroke The researchers conducted a nationwide, observational study using Czech national health registry data from 2015 to 2024 to evaluate the real-world impact of GLP-1 initiation after nonfatal MI or stroke among patients with diabetes

However, when combined with GLP1RA, GIP enhances GLP1R activity, which may explain superior weight loss compared to GLP1RA alone