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2025 May 1;64(5):2385-2394

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Implement all strategies, hydration, fiber, magnesium, movement, before constipation becomes severe

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Many factors influence bodyweight regulation: Intrinsic factors such as: Genetics and epigenetics The complex biology of adipose tissue Adipokine signaling Appetite regulation pathways The microbiome Insulin sensitivity Circadian rhythms Hormones Extrinsic factors such as: Diet Exercise Lifestyle Stress Habits Associated with Sustained Weight Loss Many people find long-term maintenance of weight loss is the most difficult aspect of successful weight management