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For scientific consultants, this evolution presents both challenges and opportunities

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Nevertheless, bone consequences of intentional weight loss interventions in PwO are well known: (i) significant weight loss induced by caloric restriction and bariatric surgery results in accelerated bone turnover and bone loss, and (ii) unlike caloric restriction interventions, PwO experience a substantial deterioration in bone microarchitecture and strength associated with an increased risk of fracture after bariatric surgery especially malabsorptive procedures

current management largely focuses on weight reduction and lifestyle modification

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However, today's diets are dominated by excessive salt intake, which significantly impacts individual and population health