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Multiple biological activities of GLP-1 GLP-1 analogues stimulate glucose-dependent insulin secretion, dampen inappropriately high glucagon secretion, slow gastric emptying and reduce food intake [28]

Beyond that, the fat-loss benefit is small, but the amount of muscle youd lose will increase 4,5

Lipid Metabolism Orforglipron significantly reduced triglycerides and non-HDL cholesterol, indicating reduced atherosclerotic risk

18 A 44-week study was conducted to compare the efficacy and safety of sitagliptin/metformin with metformin monotherapy in treatment-naive patients with type-2 diabetes

Patients might have a fever and look unwell

Low-aroma foods: Blander choices like rice, oats and bananas can be easier on the stomach during dose adjustments