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We show the release of NE into the intestinal lumen in vitro and the activation of the sympathetic nervous system by acute administration of GLP-1RA with a concomitant rapid increase in E

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But there was a clear consensus among experts at the ASAM conference: more research is needed

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When selecting the most appropriate agent, a comprehensive review of all head-to-head data indicates that liraglutide appears to still offer the best A1C and weight reduction, while the once weekly agents may cause less GI AEs compared with the once daily or twice daily options

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