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Patients with pre-existing cardiac arrhythmias or significant cardiovascular disease should be monitored appropriately when initiating GLP-1 therapy, though these conditions are not absolute contraindications

As gastrointestinal cancer outcomes were secondary or exploratory endpoints in the majority of included trials, these analyses are inherently vulnerable to type I error, outcome misclassification, and inadequate statistical power

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Patients prescribed DOACs (apixaban, rivaroxaban, edoxaban, dabigatran) require renal function monitoring at least annually, and more frequently in those aged over 75, with low body weight, intercurrent illness, or chronic kidney disease