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Theyre present in the gut, but also in the brains reward-processing regions, the same pathways that govern cravings

All GLP-1 medications start low and gradually increase every 4 weeks (weekly formulations) or weekly (daily formulations) to minimize gastrointestinal side effects

This approach delays reaching your therapeutic dose slightly but often eliminates headache complaints entirely

The balanced engagement of these three receptors distinguishes retatrutide from other investigational and approved therapies in the incretin class

This effect may diminish over time (tachyphylaxis) and varies between individuals, as noted in the Wegovy SmPC

APPENDIX 1: TABULATED DATA 22