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Specifically, the inclusion of the SURPASS-CVOT trial, which compares tirzepatide against dulaglutide rather than semaglutide, is explicitly justified as it provides vital contextual cardiovascular outcome data for tirzepatide in the absence of a completed head-to-head cardiovascular trial between the two primary agents

The hormonal and neurological changes that made sticking to a deficit easier disappear when you stop the medication

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The effect was only statistically significant in women, researchers said