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This oxidative stress-mediated autophagy effect was significantly attenuated by GLP-1 treatment
1 Engs paper, published in the Journal of Biological Chemistry , noted something strange: exendin-4 shared 53% of its amino acid sequence with a human gut hormone called glucagon-like peptide-1 (GLP-1), which had been characterized just a few years earlier
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The trial enrolled 445 adults with obesity or overweight who also had knee osteoarthritis, and it tracked outcomes over 68 weeks
