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None of the patients from the case series was rechallenged with GLP-1 RAs due to safety concerns

Weight regain occurs when incretin analogues are ceased

Dror Dicker 5,6 MATERIALS AVAILABLE Slide Relationship Between Mean CagriSema Dose and Weight Loss in the REDEFINE 1 Trial W

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Nevertheless, this study has several limitations, with the first one being the absence of a comparator arm due to its observational nature, not allowing us to quantify the extent to which semaglutide and lifestyle intervention contributed to weight loss