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Our results indicate that exendin-4 increased CSMC cAMP levels in a dose-dependent fashion, indicating that GLP-1R mediates its effects in CSMCs through activation of adenylyl cyclase, leading in turn to cAMP-dependent activation of various second messenger pathways (Figure 6C)

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NNC5840: Smarter, Not Louder EVIDENCE TIER, PRECLINICAL / MECHANISTIC The other half of the precision story is harder to translate but, intellectually, may be the most important section in this entire article