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Still, the exact processes behind these effects are poorly understood, and studies in humans are limited

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The SUMO-1 and SUMO-4 trials tracked tirzepatide use for up to two years, showing sustained weight reduction and improved metabolic markers without concerning safety signals in most participants

During the TRIUMPH-1 trial, the 4 mg dose had fewer adverse event-related discontinuations than the placebo

Remnant particles readily penetrate the arterial wall, similar to LDL, but do not require oxidative modification for macrophage uptake and can be taken up unregulated, leading to foam cells and atherosclerosis

These findings are supported by the results of a phase 2 dose-ranging trial of semaglutide in obesity, which reported a weight loss of 11.6% and 13.8% for 0.2 mg and 0.4 mg semaglutide daily dose (equivalent to 1 mg and 2.8 mg weekly dose) [17]