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One non-randomized open-label study, published over 2 separate articles, showed that 4-week liraglutide led to an improvement in a test of executive functioning (and possibly other cognitive measures) 178 and related increase in fronto-striatal volumes 179 , partly moderated by BMI and insulin resistance changes, in 19 people diagnosed with bipolar disorder or major depression

More strikingly, 45 percent of women in the combination group achieved the 20 percent weight loss threshold compared to only 18 percent without HRT

But: Weight loss magnitude overlaps with lower-to-mid range injectable GLP-1 outcomes Convenience and adherence may change real-world effectiveness No fasting window or timing constraints give orforglipron a usability advantage over oral semaglutide This isnt about replacing injectablesits about expanding the menu

[DOI] [PubMed] [Google Scholar] 48.Baggio LL, et al

Anthem Blue Cross Blue Shield plans in Arizona may cover telehealth appointments for weight loss management and GLP-1 prescribing

And they're telling me hormones have absolutely nothing to do with women's metabolic health