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Nauck M, Frid A, Hermansen K, et al, for LEAD-2 Metformin Study Group
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2) insulin resistance leading to decreased glucose uptake by peripheral tissues (muscle and adipose)
These agents have demonstrated particular promise, with semaglutide showing a 40% reduction in AD risk in subjects with T2DM compared to other GLP-1 receptor agonists in a previous cohort study [70]
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