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Plain-English translation: in studies to date, many participants lost a significant proportion of their starting weight over about a year, and their metabolic markers generally moved in a healthier direction

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In cases of severe vomiting, poor oral intake, or risk of dehydration (such as during significant infection), seek medical advice promptly

Examples might include individual tolerability, adverse effects, a carefully planned maintenance approach or another circumstance where the potential benefit outweighs the additional uncertainty